Platelet Microparticle Controversial Role in Cancer

The Role of Platelet Microparticle Associated microRNAs in Cellular Crosstalk

Platelet is an anucleate cell containing abundant messenger RNAs and microRNAs (miRNAs), and their functional roles in hemostasis and inflammation remain elusive. Accumulating evidence has suggested that platelets can actively transfer RNAs to hepatocytes, vascular cells, macrophages, and tumor cells. The incorporated mRNAs are translated into proteins, and miRNAs were found to regulate the gen...

Role of P2Y receptor subtypes in platelet-derived microparticle generation.

Microparticles are shed from the platelet membrane upon platelet activation by strong agonists, and they aid in clot formation. As the P2Y1 and the P2Y12 receptors differentially contribute to different platelet functions, we studied the relative contribution of the P2Y1 and P2Y12 receptors to microparticle formation from platelets. The P2Y12 receptor antagonist AR-C 69931MX, but not the P2Y1 r...

The platelet microparticle proteome.

Platelet-derived microparticles are the most abundant type of microparticle in human blood and contribute to many biologically significant processes. Here, we report the first proteomic analysis of microparticles generated from activated platelets. Using 1D SDS-PAGE and liquid chromatography coupled to a linear ion trap mass spectrometer, the identification of 578 proteins was accomplished usin...

[Colorectal cancer: controversial role of meat consumption].

Diet is supposed to influence the colorectal cancer etiology, but the precise causative factors are yet unknown. International ecological studies show a strong correlation between meat consumption and the colorectal cancer incidence. Most case-control studies (22 of 29) show an increased risk to develop a colorectal cancer for those eating higher amounts of meat. In contrast, only 2 out of the ...

Platelet and platelet - derived microparticle studies in severe sepsis